BH Protocol™ · Human Healthspan Intelligence OS

The Framework

Nine Physiological Axes

Each axis aggregates validated biomarkers into an axis score. The nine axis scores resolve into the Longevity Anchor Index™ (LAI™) and the Health Coherence Index™ (HCI™).

Cardiac-Mitochondrial Vitality

VO₂ max, cardiac output, mitochondrial energy production, HRV. The energetic engine of biological health.

Neuro-Cognitive Coherence

Homocysteine, thyroid function (TSH/FT4), sleep architecture, REM quality. Brain health and cognitive vitality.

Cardiometabolic Regulation

ApoB, LDL-C, HbA1c, fasting insulin, HOMA-IR, uric acid. The most causally established axis for longevity outcomes.

Immuno-Inflammatory Balance

hsCRP, full blood count, neutrophil:lymphocyte ratio, eGFR. Inflammaging — the central driver of biological aging.

MSK Integrity & Function

Grip strength, gait speed, sit-to-rise test, body composition (DEXA). Functional reserve and sarcopenia prevention.

Gut-Microbiome Ecology

Dietary fibre, plant diversity, microbiome sequencing. The gut–brain–immune connection.

Endocrine-Circadian Alignment

Vitamin D, testosterone, DHEA-S, cortisol, sleep timing regularity. Hormonal intelligence and circadian coherence.

Psycho-Emotional Resilience

PHQ-9, GAD-7, PSS-10, mood trajectory, sleep quality, mindfulness compliance. Psychological reserve and adaptive capacity.

L² AI Coherence Index

Longevity Domain × Lifecare Domain. AI-weighted objective–subjective coherence. The integration score.

Clinical Application

BH Protocol™ Five Care Phases

The LAI™ score places every patient in a defined care phase — and each phase carries its own clinical posture, monitoring frequency and intervention intensity.

Phase 0

Reconcile

Active treatment

Active medical management. Biological conflict resolution. BH Protocol™ captures the biological nadir.

Phase I

Restore

LAI™ 25–44

Post-crisis stabilisation. Protect mitochondrial reserve. Conservative intervention. High-frequency monitoring.

Phase II

Recharge

LAI™ 45–64

Active biological recovery. Drive multi-axis improvement. Full protocol activation. Maximum intervention window.

Phase III

Resilience

LAI™ 65–84

Optimised healthspan maintenance. Biological systems coherent. Sustain gains. Prevent regression.

Phase IV

Rejuvenate

LAI™ ≥ 85

Active biological age reversal. Epigenetic clock regression. Elite longevity medicine.

Clinical Evidence

N=1 Index Case

Unedited longitudinal data from the BH Protocol™ index case. No pharmacological augmentation of any individual biomarker.

↓80%Insulin resistance reversal29.9 → 6.1 mIU/L · No pharmacotherapy

↓51%LDL-C reduction5.14 → 2.5 mmol/L · 18 months

↓51%ApoB reduction1.61 → 0.79 g/L · Atherogenic burden resolved

↓57%NT-proBNP42 → 18 pg/mL · Cardiac recovery

↓47%hsCRP3.2 → 1.7 mg/L · Inflammaging reduction

+39%LAI™ trajectoryScore 56 → 78 · 27 months

N=1 Index Case: Dr Billy Hardie, M.B.,B.S. (NUS) — DLBCL post Pola-R-CHOP. 27-month longitudinal dataset. 4 blood panel timepoints. Unedited real data. No pharmacological augmentation of any individual biomarker. Provisional Patent #1 — BH Protocol™ Human HealthSpan OS, SG IPOS · USPTO · WIPO PCT.

A single-subject longitudinal dataset is a proof of concept, not a controlled trial. Results are not generalisable and do not constitute evidence of efficacy in any other individual.

Full Health Intelligence Report™

The complete longitudinal report and the AURUM™ LifeApp v7 environment are available to registered clinicians, partners and research collaborators only. Access is issued individually after registration.

Register for Access

Intellectual Property

Provisional Patent #1

BH Protocol™ Human HealthSpan Operating System. Filed SG IPOS · USPTO · WIPO PCT. Invented by Dr Billy Hardie, M.B.,B.S. (NUS). Held by Ark Active Pte Ltd, UEN 201322195G.